With the slit lamp, patients with PDS and pigmentary glaucoma demonstrate bilateral liberation of iris pigment in the anterior chamber. Often, this is seen as a granular brown vertical band along the corneal endothelium, known as Krukenberg's spindle.

You may also see pigment dusting on the lens, the surface of the iris and at Schwalbe's line. With the gonio lens, you may see dense pigmentation, which looks similar to melted chocolate, covering the trabecular meshwork in 360 degrees, though it will be most prominent in the inferior quadrant. The angle itself remains patent, and in some cases appears atypically wide open. Radial, spoke-like transillumination defects of the mid-peripheral iris are another common finding. While the intraocular pressure is normal in PDS, it may rise sharply in cases of pigmentary glaucoma, particularly after vigorous exercise or pharmacologic dilation. Likewise, PDS presents with a normal optic nerve appearance, while patients with pigmentary glaucoma manifest evidence of glaucomatous optic atrophy and associated field loss.

Management

As PDS has no direct ramifications on ocular health or vision, other than potential future development of pigmentary glaucoma, consider these patients to be glaucoma suspects and monitor for IOP spikes and optic nerve changes three to four times per year; perform threshold visual fields and gonioscopy annually. Patients with confirmed pigmentary glaucoma are best managed using topical miotics as a first-line of defense.

Miotics are preferable to beta-blockers or adrenergic agents because they have a dual effect: (1) lowering the IOP and (2) contracting the pupil, thereby pulling the peripheral iris away from the zonular fibers. Begin with 1 or 2% pilocarpine solution QID; in younger patients consider 4% pilocarpine ointment administered once daily at bedtime as an alternative. If this is unsuccessful in controlling the IOP, or if a pre-presbyopic patient is affected by miotic side effects, consider adding an additional medication such as timolol, dipivefrin, dorzolamide or latanoprost.

Progressive, poorly responsive cases may require surgical intervention, either argon laser trabeculoplasty or filtering surgery. More recently, some doctors have recommended laser peripheral iridotomy in patients with evidence of posterior iris bowing to flatten the iris profile. While this procedure has demonstrated success in select cases, it is still somewhat controversial.

CLINICAL PEARLS

Pigment dispersion syndrome in and of itself is a relatively benign condition. Pigmentary glaucoma, on the other hand, may lead to irreversible vision loss if not detected early and managed accordingly.

As with any case of glaucoma, you must differentiate pigmentary glaucoma from other secondary glaucomas such as exfoliative, uveitic and angle recession.

Pigmentary glaucoma, unlike POAG, is not typically a slow, insidious disease-often the onset and progression are quite rapid. Consequently, you shouldn't use the "watch and wait" attitude of POAG. However, because pigmentary release can end abruptly, the condition may "burn out" over time.