Histoplasmosis is contracted by inhaling dust that carries the fungal spores. Its effect on the body can vary widely in severity from one person to another. Many carriers have no symptoms at all, but those with mild exposure may experience flu-like symptoms and mild respiratory infections. Histoplasmosis is more likely to become a serious problem in people who already have a weakened immune system.

The fungus may affect the eye by causing small areas of inflammation and scarring of the retina. These are called "histo spots" and may be found in both eyes. Their affect on vision depends on the location of the scars. Scarring in the peripheral area of the retina may have little or no impact on vision, while a central scar affecting the macula may cause a prominent blind spot.

Most people with histo spots in the retina are totally unaware of their presence unless the central vision is affected. Studies indicate that only about 5% of those with histo spots are at risk of losing vision. Scientists have been unable find a link between the patients with minor histo spots and those who develop a severe loss of their central vision.

Signs and Symptoms

Many patients with histo spots in their eyes have no symptoms. Others may experience the following: distorted vision, blind spots, floaters.

Detection and Diagnosis

Ocular histoplasmosis is detected with a dilated examination of the retina using ophthalmoscopy. It is usually diagnosed based on its distinctive appearance and characteristics.

Treatment

Ocular histoplasmosis usually requires no treatment except when abnormal blood vessels develop in the central retina. For these patients, Intravitreal injection of Avastin, like that in macular degeneration, is effective in most cases. Regular eye exams and routine use of an Amsler Grid to monitor central vision is recommended for anyone with histo spots.